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在卵泡胺诱导的喘中的黄类药物的治疗潜力在小鼠模型中
Vedpal Singh1, Rohit Singh2, Sangai P Dhanabal3
1Department of Pharmacognosy, College of Pharmacy, JSS Academy of Technical Education, Noida, UP, India.
Journal of complementary & integrative medicine
|February 14, 2024
概括
来自Desmodium triquetrum的黄素,包括Baicalein,Naringin和Neohesperidin,在喘模型中显著降低了呼吸道炎症. 这些天然化合物通过向促炎途径,显示出作为替代性喘治疗的潜力.
科学领域:
- 植物化学 植物化学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 喘影响全球数百万人,需要新的治疗策略.
- 印度传统医学使用Desmodium triquetrum治疗过敏.
- 黄酸是植物衍生化合物,具有已证明的抗喘特性.
研究的目的:
- 为了研究三种黄类药物的抗喘潜力: Baicalein,Naringin和Neohesperidin. 为了研究三种黄类药物的抗喘潜力.
- 在喘模型中评估这些黄类素对关键炎症标志物的影响.
- 探索它们在抑制促炎途径中的作用.
主要方法:
- 采用了一个卵胺诱导的喘模型.
- 对白细胞,亚酸盐,酸盐,TNF,IL-4和IL-13的支气管膜洗液的分析.
- 在肺组织中测量骨髓氧化酶 (MPO) 和甲酸 (MDA).
主要成果:
- 卵素挑战显著增加的促炎性细胞因子.
- 黄类药物治疗显著降低了呼吸道炎症和高反应性.
- 组织病理学检查证实了黄类药物的抗炎作用.
结论:
- 研究的黄类药物显示出作为补充和替代性喘治疗的潜力.
- 这些化合物可能会累积起作用,降低细胞因子水平和炎症细胞计数.
- 建议使用呼吸系统的作用机制,包括抑制促炎途径.
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