晚上与早晨的剂量方案是高血压的药物治疗
Chuncheng Wu1, Ping Zhao2, Ping Xu2
1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
The Cochrane database of systematic reviews
|February 14, 2024
概括
晚上和早上服用血压药物对结果没有显著差异. 需要更多的研究来证实晚上用药对高血压管理的有效性.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 循环节律影响血压水平,使得24小时控制对抗高血压治疗至关重要.
- 减少不良心血管结果是高血压管理的首要目标.
- 本综述是2011年首次发表的最新研究.
研究的目的:
- 为了评估每天服用一次抗高血压药物的晚上和早晨剂量的有效性.
- 评估对死亡率,心血管事件,不良事件和降低血压的影响.
- 为了在患有初级高血压的个体中比较这些影响.
主要方法:
- 包括27个随机对照试验 (RCT),其中3016名参与者患有初级高血压.
- 分析了使用元分析对死亡率,不良事件和血压变化的数据.
- 使用GRADE方法评估证据的确定性.
主要成果:
- 在所有原因的死亡率,严重不良事件,整体不良事件或治疗中止方面,在晚上和上午剂量之间没有发现显著差异.
- 关于对心血管结果和降低血压的有效性的证据非常不确定,这是由于有限的数据和试验缺陷.
- 大多数被纳入的试验具有高偏差风险,特别是在分配隐和选择性报告方面.
结论:
- 没有足够的证据来确定晚上或早晨服用抗高血压药物是否对心血管结果或不良事件更有益.
- 对证据的信心,比较晚上与早上的剂量24小时降低血压的证据是非常低的.
- 这些发现可能不适用于多种抗高血压药物治疗方案的患者.
相关概念视频
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
61
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
61
01:01Dosage Regimen: Fixed Dose
1.9K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
1.9K
01:15Drug Dosage Regimen: Overview
3.5K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.5K
01:24Rational Dosage Regimen: Maintenance Dose and Loading Dose
4.1K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
4.1K
01:16Insulin: Dosing Regimen and Adverse Effects
173
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
173
01:28Drug Therapy
44
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
44