在药物诱导睡眠内镜期间,哨兵中心事件 (SCent) 的发生率
Julianna G Rodin1, Manan H Parekh1, Yi Cai1
1Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
概括
在药物诱导睡眠内镜 (DISE) 期间,近一半的患者观察到中心性和混合性呼吸暂停事件 (SCents). 大多数患者在13分钟内转变为阻塞性事件,这突显了识别这些初始中心事件的重要性.
科学领域:
- 睡眠医学 睡眠医学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 药物诱导睡眠内镜 (DISE) 对于诊断阻塞性睡眠呼吸暂停 (OSA) 是至关重要的.
- 在DISE期间中心和混合性呼吸暂停事件的存在和时间尚不清楚.
- 最近的进展允许同时监测空气流,呼吸力度和视频内镜.
研究的目的:
- 调查DISE期间的哨戒中心和/或混合事件 (SCents) 的发生,时间和特征.
- 为了比较中央/混合和阻塞性事件之间的毛皮,口腔,舌头和上 (VOTE) 分类.
- 在程序期间评估从中央/混合到阻塞事件的过渡.
主要方法:
- 在高等保健学术医疗中心进行前性单一队列研究.
- 在2020年6月至2022年11月期间,103名患者接受了DISE.
- 同时记录鼻腔气流,胸腔腹部力度和视频内镜;使用学生的T测试或千平方测试分析数据.
主要成果:
- 几乎一半的队列 (46%) 经历了至少一个SCent.
- 大多数SCents患者 (95.7%) 在大约8分钟内过渡到阻塞性病理,预计95%的患者在12.57分钟内过渡到阻塞性病理.
- 在61.2%的SCents患者中,在中心/混合和阻塞事件之间观察到VOTE得分的显著差异.
结论:
- 中央事件在DISE期间很常见,在大多数患者中都会先发生阻塞性事件.
- 意识到最初的中心事件和延迟的VOTE得分可能会提高诊断准确度.
- 这些发现表明需要考虑DISE期间气道崩的动态性质.
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