在患有肠道阻塞的患者中,术前系统性免疫炎症指数和术后性败血症之间的关联:一项回顾性观察队列研究
Jirong Yang1, Taojia Ran1, Xiaoyu Lin1
1Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
Immunity, inflammation and disease
|February 14, 2024
概括
术前系统性免疫炎症指数 (SII) >1792.19是肠道阻塞手术后发生术后败血症的重要危险因素. 这一发现有助于预测和管理手术患者的败血症风险.
科学领域:
- 手术瘤学手术瘤学
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 败血症是肠道阻塞手术后危及生命的并发症.
- 确定术后败血症的预测标志物对于患者的治疗结果至关重要.
研究的目的:
- 调查术前系统性免疫炎症指数 (SII) 与术后败血症发生率之间的关联.
- 确定SII是否可以在接受肠道阻塞手术的患者中作为败血症的预测生物标志物.
主要方法:
- 对371名接受肠道阻塞手术的患者进行了回顾性分析.
- 系统性免疫炎症指数 (SII) 在手术前计算,并以最佳切线值 (>1792.19) 进行二分化.
- 进行了多变量逻辑回归和子组分析,以评估SII和术后败血症之间的关联.
主要成果:
- 手术后败血症发生在16.17%的患者 (60/371).
- 术前SII>1792.19显著与术后败血症风险增加有关 (调整后OR=2.12,95%CI: [1.02-4.40]).
- 在SII和其他临床因素 (年龄,高血压,ASA分类等) 之间没有发现显著的相互作用. 有关败血症风险.
结论:
- 术前SII>1792.19是患有肠道阻塞的患者手术后败血症的独立风险因素.
- 术前SII升高可能表明炎症状况升高,使患者在手术后易患败血症.
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