GIST患者的转诊模式:来自全国性研究的数据
Evelyne Roets1, Nikki S Ijzerman2, Vincent K Y Ho3
1Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Acta oncologica (Stockholm, Sweden)
|February 14, 2024
概括
在非参考中心诊断的胃肠道 stromal 瘤 (GIST) 患者往往缺乏全身治疗,特别是转移性病例. 在荷兰优化转诊策略可以改善GIST患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 胃肠道 stromal 瘤 (GIST) 是瘤学中的一个重大挑战.
- 专业参考中心和一般非参考中心之间可能存在治疗差异.
研究的目的:
- 为了比较GIST患者的特征,转诊模式和荷兰参考和非参考中心的治疗.
- 评估中心类型对全身疗法管理和结果的影响.
主要方法:
- 使用荷兰癌症注册表和荷兰全国病理学数据库 (2016-2019) 的回顾性队列研究.
- 患者分为参考中心 (诊断或转诊) 和非参考中心 (没有转诊) 组.
- 对转诊率,突变分析,全身疗法和手术结果的分析.
主要成果:
- 包括1,550名GIST患者;87%在非参考中心诊断.
- 高风险 (62.2%) 和转移性 (67.2%) GIST患者的转诊率更高.
- 系统治疗在转移性GIST的非参考中心较少 (65.9%对94.1%). 基因突变分析在参考中心更常见 (96.9% vs 87.6%).
结论:
- 在非参考中心的转移性GIST患者中,很大一部分没有接受全身治疗.
- 荷兰GIST患者的转诊优化是有必要的.
- 需要进一步的研究,以了解转移性GIST治疗不足的原因.
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