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肠道微生物群通过上皮细胞MyD88调节宿主黑激素的产生

Bingnan Liu^1,2, Lijuan Fan^1,2, Youxia Wang^1,2

¹State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, China.

|February 14, 2024

概括

肠道细菌会影响宿主的黑激素水平,降低血清中的黑激素,增加结肠中的黑激素. 特定的细菌,如Lactobacillus reuteri和Escherichia coli激活了调节氨酸生产的途径.

科学领域:

微生物学微生物学
内分泌学在内分泌学.
免疫学免疫学免疫学

背景情况:

黑色素调节昼夜节律,炎症和肠道屏障.
肠道微生物群在宿主黑激素生产中的作用尚不清楚.
现有的研究澄清了黑激素对肠道微生物群的影响,但不是反之.

研究的目的:

调查肠道微生物群对宿主氨酸生产的贡献.
阐明肠道微生物群影响黑色素水平的机制.

主要方法:

使用肠道微生物乱的小鼠模型 (用抗生素治疗和无细菌).
进行了便微生物群移植 (FMT),以确认微生物的影响.
研究了特定的细菌物种 (Lactobacillus reuteri,Escherichia coli) 和分子通路 (TLR2/4/MyD88/NF-κB).

主要成果:

抗生素治疗和无细菌条件改变了黑色素水平:血清下降和结肠增加.
FMT证实了肠道微生物群对宿主的黑激素水平的影响.
乳杆菌reuteri和大肠杆菌模仿了这些效应.
这些细菌激活了TLR2/4/MyD88/NF-κB通路,升调了阿里胺N-乙烯转移酶 (AANAT).
结肠细胞中的MyD88缺乏消除了微生物群对结肠黑激素的影响.

结论:

肠道微生物群显著调节宿主黑激素的产生.
确定了一种涉及细菌激活TLR/NF-κB信号和AANAT表达的特定机制.
这一发现为与黑色素相关的疾病提供了潜在的治疗策略.

关键词:

一个AANATAT一个AANAT 埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.黑色素是什么黑色素是什么黑色素是什么我的D8888是什么意思牛乳杆菌reuteri 牛乳杆菌reuteri 是一个

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