对于65岁及以上的人群,他类药物对跌倒和体育活动的影响:系统性审查
Emily Densham1, Elaney Youssef2, Oscar Ferguson3
1Brighton and Sussex Medical School, Brighton, UK. e.densham1@uni.bsms.ac.uk.
European journal of clinical pharmacology
|February 14, 2024
概括
这次审查发现,在老年人中,他类药物使用与体育活动或跌倒风险之间没有显著的联系. 个人风险益处评估对于药物决定至关重要.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 类他类药物被广泛使用,肌肉衰弱是已知的副作用.
- 类药物对老年人身体活动和跌倒的影响尚不清楚.
- 这项研究调查了65岁及以上个体的他类药物使用和身体功能之间的关系.
研究的目的:
- 调查他类药物使用与身体活动水平之间的关系.
- 探讨使用他类药物与65岁及以上成年人跌倒风险之间的关联.
主要方法:
- 在多个数据库 (MEDLINE,Embase,CINAHL,PsycINFO) 进行了全面的文献搜索.
- 包括的研究重点是肌肉力量,步行速度,平衡和跌倒的发生率.
- 由于数据异质性,采用了叙事综合方法,对偏差进行了批判性评估.
主要成果:
- 审查中包括了20篇文章.
- 总体趋势表明,他类药物对身体活动参数没有显著的负面影响.
- 在使用他类药物和增加跌倒风险之间没有发现显著的关联,特别是在调整后的研究中.
结论:
- 在65岁及以上的成年人中,使用他类药物和身体活动或跌倒风险之间没有明确的关系.
- 这些发现表明,他类药物可能不会对这个人口群体的身体功能产生不利影响.
- 对药物风险和益处的个性化考虑是必不可少的.
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