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在多重创伤患者中,入院葡萄糖水平是否可以独立预测凝血病? 一个追溯的队列分析

Jorge Mayor¹, Pascal Gräff², Vera Birgel³

¹Department of Trauma Surgery, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany. mayorramirez.jorge@mh-hannover.de.

European journal of trauma and emergency surgery : official publication of the European Trauma Society

|February 14, 2024

概括

高摄入葡萄糖水平预测创伤患者的凝血病. 监测血糖可以帮助识别患有更高出血并发症和死亡风险的患者.

科学领域:

创伤研究研究创伤研究
临床生物化学临床生物化学
流血性休克管理的管理.

背景情况:

凝血病在多重创伤患者中很常见,增加了发病率和死亡率.
住院高血糖是严重受伤患者出血性休克和死亡率的已知预测因素.

研究的目的:

评估入院葡萄糖水平作为多次受伤患者凝血病的独立预后因素.

主要方法:

在一级创伤中心对913名多重创伤患者进行了回顾性队列研究 (2005-2020年).
凝血病定义为国际正常化比率 (INR) >1.4和/或激活血栓形成时间 (APTT) >40秒.
统计分析包括ANOVA,ROC和多变量逻辑回归来确定风险因素.

主要成果:

188名患者 (20%) 呈现出凝血病,死亡率较高 (26%对5.0%).
凝血病患者的平均入院葡萄糖明显高于凝血病患者 (10.09 mmol/L对比7.97 mmol/L).
摄入葡萄糖 (切断值12.35 mmol/L) 预测了凝血病 (OR 1.99),与血红蛋白,碳酸盐和乳酸盐也有关.

结论:

入院血糖是创伤患者凝血病的重要独立预测因子.
监测高血糖症可以识别需要更密切观察和管理的高风险个体.

关键词:

接收血液中的葡萄糖.凝血病是一种凝血病.过高糖血症是什么意思多重创伤是多重创伤的一种.

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