开发问题来评估和衡量患者从乳腺癌辅助内分泌治疗中感知到的生存益处:混合方法试点研究
Bernard Tawfik1,2, Kendal Jacobson3, Ursa Brown-Glaberman3,4
1University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA. btawfik@salud.unm.edu.
Clinical and experimental medicine
|February 14, 2024
概括
患有乳腺癌的女性显著高估了他们的10年整体存活率,从辅助内分泌治疗中受益. 这项研究开发并测试了一些问题,以准确地测量这种感知好处.
科学领域:
- 在瘤学瘤学.
- 医疗保健服务研究 医疗服务研究
- 患者报告的结果
背景情况:
- 辅助内分泌治疗对于乳腺癌管理至关重要,旨在改善整体存活率 (OS).
- 了解患者对治疗益处的看法对于明智的决策和坚持治疗至关重要.
- 现有的方法可能无法充分捕捉患者对复杂生存益处的细微理解.
研究的目的:
- 开发和验证测量女性从辅助内分泌治疗中感知到的益处的问卷类型.
- 为了测试患者低估了辅助内分泌治疗的OS益处的假设.
- 为了比较患者自我评估的OS益处与个性化风险预测模型的结果.
主要方法:
- 混合方法研究涉及定性访谈和重点小组,以改进9种初始问题类型.
- 使用图形和散文格式开发和选择最佳问题,以评估感知到的OS好处.
- 在53名乳腺癌患者中,患者估计的OS益处与PREDICT模型计算的比较.
主要成果:
- 三个修改后的问题有效地捕捉了患者对OS益处的看法.
- 患者估计OS益处为42%,明显高于PREDICT模型计算的4.4% (p < 0.001).
- 该研究包括一个多元化的人口,42%的西班牙裔,30%的农村和47%的低收入参与者.
结论:
- 患有乳腺癌的女性显著高估了他们从辅助内分泌治疗中获得的10年OS益处.
- 为了准确评估患者对治疗益处的理解,需要多种问题模式,特别是在不同人群中.
- 这些发现突出了感知和实际生存益处之间的关键差距,影响了治疗讨论和坚持.
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