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皮质-大脑干电路减弱了生理应激反应能力
Sebastian A Pace1, Ema Lukinic1, Tyler Wallace1
1Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
The Journal of physiology
|February 14, 2024
概括
腹中前额叶皮层 (vmPFC) 通过投射到正面腹侧髓 (RVLM) 直接影响压力反应. 这种电路激活减少了两性压力诱导的皮质释放,突出了压力评估和生理反应的关键途径.
科学领域:
- 神经科学是一个神经科学.
- 压力生理学 压力生理学
- 行为内分泌学 行为内分泌学
背景情况:
- 压力刺激会触发多系统反应,以维持平衡.
- 腹侧髓 (VM) 对于同情活动和生理应激适应至关重要.
- 腹中前额叶皮层 (vmPFC) 参与认知压力评估和生理反应.
研究的目的:
- 为了研究直接的神经电路连接vmPFC到正面腹侧髓 (RVLM).
- 确定vmPFC-RVLM电路在调解生理应激反应中的功能作用.
- 探索vmPFC-RVLM电路对压力反应性的性别差异的影响.
主要方法:
- 利用基因编码的前向和逆向通道标记器来绘制雄性和雌性大鼠中的vmPFC-RVLM连接.
- 采用光遗传终端刺激来激活vmPFC对RVLM的谷氨基质投射.
- 评估了电路刺激对血糖,皮质和情感行为反应在克制压力期间的影响.
主要成果:
- 压力激活的vmPFC神经元投射到腹侧神经元中的 катехоламинергия神经元.
- 在压力期间,vmPFC-RVLM电路刺激抑制了男性的血糖反应和男性的皮质反应.
- 电路刺激优先激活RVLM内的非催化剂和抑制性神经元,而不会改变情感行为.
结论:
- 有一个直接的vmPFC-RVLM投影存在,调节内分泌应激反应.
- 这种电路可能通过激活RVLM中的局部抑制神经元来减少压力反应.
- 在RVLM中的vmPFC突触的刺激/抑制平衡可能对调节压力结果至关重要.
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