电子尼古丁输送系统用于戒烟
Reto Auer1, Anna Schoeni1, Jean-Paul Humair1
1From the Institute of Primary Health Care (BIHAM) (R.A., A. Schoeni, M.J.S., M.L.H., K.T., S.B., J.J., M.F., N.R.) and the Departments of General Internal Medicine (M.J.S., N.R.) and Pediatrics (J.J.), Bern University Hospital (Inselspital), University of Bern, Bern, the University Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne (R.A., I.J.-S., I.B., N.S., N.B.H., A.B.), the Department of Primary Care Medicine, University Hospitals of Geneva, Geneva (J.-P.H., R.C.T.), the Epidemiology, Biostatistics and Prevention Institute, University of Zurich (A.F., A. Strassmann), Arud Center for Addiction Medicine (P.B.), and the Institute of Primary Care, University and University Hospital of Zurich (P.B.), Zurich, the Lung Center, Kantonsspital St. Gallen, St. Gallen (F.B., M.B.), the University of Basel, Basel (F.B., M.B.), and the Population Health Laboratory, University of Fribourg, Fribourg (S.B.) - all in Switzerland; and the Department of Medical Pharmacology, Hôpital Pitié-Salpêtrière, Sorbonne Université, Paris (I.B.).
电子尼古丁输送系统 (电子烟) 在加入标准咨询时显著增加了戒烟率. 这项研究提供了电子烟作为戒烟援助的证据.
科学领域:
- 临床试验 临床试验
- 公共卫生 公共卫生
- 成 药物 药物 药物 药物
背景情况:
- 电子尼古丁输送系统 (电子烟) 正被探索为旨在戒烟的烟草吸烟者提供一种工具.
- 关于电子烟在戒烟方面的有效性和安全性的证据至关重要.
研究的目的:
- 评估电子烟作为标准戒烟咨询的辅助产品的有效性.
- 评估希望戒烟的吸烟者中与电子烟使用相关的安全性和戒烟率.
主要方法:
- 一个开放的,受控的试验随机选择了1246名成年吸烟者,接受电子烟加标准咨询或仅接受标准咨询.
- 主要结局是6个月后生物化学验证的持续戒烟.
- 二级结局包括自我报告的戒烟和尼古丁戒断,呼吸道症状和不良事件.
主要成果:
- 与对照组 (16.3%) 相比,在电子烟组 (28.9%) 中,验证的持续戒烟率更高.
- 6个月后,吸烟戒断率为59.6%的电子烟者,而没有电子烟的吸烟者为38.5%.
- 然而,电子烟组 (20.1%) 的尼古丁完全戒断率低于对照组 (33.7%).
结论:
- 将电子烟添加到标准的戒烟咨询中可以提高戒烟率.
- 电子烟证明作为戒烟辅助剂的有效性,尽管完全禁用尼古丁需要进一步研究.
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