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Updated: Jul 3, 2025

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在细胞重编程过程中通过矩阵刚度对表观遗传状态的双相调节

Yang Song1, Jennifer Soto1, Sze Yue Wong2

  • 1Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Science advances
|February 14, 2024
PubMed
概括

矩阵刚性通过控制表观遗传状态和核转移酸转移酶 (HAT) 的核运输来对细胞重编程进行双相调节. 纤维细胞转化为神经元的最佳转化发生在中间硬度 (20 kPa) 时.

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