对流感疫苗接种天生的免疫反应的心理社会预测因素
Kate Ryan Kuhlman1, Arielle Radin2, Steve W Cole3
1Department of Psychological Science, School of Social Ecology, University of California Irvine, Irvine, CA, USA; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
每年接种的流感疫苗会激活天生的免疫力,在24小时内增加炎症标志物和抗病毒基因表达. 这种免疫反应受到焦虑,BMI和睡眠等因素的影响,为免疫失调提供了洞察力.
科学领域:
- 心理神经免疫学 心理神经免疫学
- 具有天生的免疫力.
- 疫苗学 疫苗学 疫苗学
背景情况:
- 实验性免疫激活有助于理解心理和免疫系统相互作用.
- 流感疫苗为研究轻度免疫刺激对心理过程的影响提供了一个模型.
- 对流感疫苗接种的急性免疫反应没有得到很好的描述.
研究的目的:
- 鉴定流感疫苗接种后炎症和抗病毒基因表达的变化.
- 在接种疫苗后检查血细胞因子和C反应蛋白 (CRP) 水平.
- 研究行为健康因素与急性免疫反应之间的关联.
主要方法:
- 接种疫苗前和接种疫苗后24小时,48小时和72小时收集的血液样本.
- 血检测CRP,IL-6,IL-10,IL-8,TNF-α和IFN-γ. 这三种类型的蛋白质的含量.
- 对1型干扰素 (IFN) 和炎症性 (INFLAM) 基因表达进行外围血液单核细胞RNA测序.
主要成果:
- 血细胞因子,CRP和IFN反应基因在接种疫苗后24小时显著增加.
- 增加的IFN基因表达与高血细胞因子和CRP相关.
- 24小时免疫反应受到焦虑,BMI,性别,睡眠和先前疫苗接种史的调节.
结论:
- 流感疫苗可靠地激活天生的免疫标记物.
- 行为健康因素调节了对疫苗接种的急性免疫反应.
- 这些发现对于研究心理神经免疫学中免疫失调的起源具有重要意义.
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