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大动脉的新和生物假体:评估流血动力学

Emily Louise Manchester¹, Selene Pirola², Sergio Pirola³

¹Department of Chemical Engineering, Imperial College London, London, United Kingdom; Department of Fluids and Environment, The University of Manchester, Manchester, United Kingdom.

Computers in biology and medicine

|February 14, 2024

概括

大动脉中的动荡,即使在大动脉门修复或更换后,也会影响血液流动和壁面压力. 尽量减少门问题,如离心率,可以减少有害的流.

科学领域:

心血管工程心血管工程
生物医学流体动力学
医疗成像医学成像

背景情况:

大动脉疾病往往需要更换或修复门.
生物假体门和大动脉膜新皮化是常见的治疗方法.
这些患者特异性门中血流干扰和动荡的影响仍未得到充分研究.

研究的目的:

在大动脉干预后,研究患者特异性大动脉的流产生的情况.
评估流对层状和流墙壁剪切应力的影响.
了解大动脉几何形状,门类型和血液动力学变化之间的关系.

主要方法:

患者特有的大动脉几何形状是从磁共振成像 (MRI) 中得出的.
4D流MRI提供了生理界限条件.
使用脉冲式的大模拟来分析流动动力学,包括流.

主要成果:

在所有模拟的大动脉中观察到动,在缩减速期间达到顶峰.
导致流的因素包括门斜率,偏心和大动脉扩张.
在心脏循环的重要部分中,乱的壁切应力超过了层状值.

结论:

流的产生受膜特征和大动脉形状的影响.
了解流壁剪压对于理解动脉壁疾病进展至关重要.
大动脉治疗的目的应该是尽量减少门异常和斜率,以减少流.

关键词:

大动脉的新囊化.大动脉门的更换生物假体是一种假体.血液的流动血液的流动计算流体动力学计算流体动力学血液动力学血液动力学大尖端模拟模拟系统这就是奥扎基手术的过程.流是什么?流是什么?流是什么?墙壁剪切应力压力是什么

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