在实验性腹腔疾病中,血管功能障碍和动脉高血压是由肠道衍生的炎症和氧化应激介导的
Karin Keppeler1, Aline Pesi2, Simon Lange1
1Center for Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Redox biology
|February 14, 2024
概括
结核病 (CeD) 通过与IL-17A相关的肠血管炎症增加心血管风险. 无质饮食逆转了这些有害影响,强调了饮食干预的重要性.
科学领域:
- 心血管研究研究心血管研究
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 结核病 (CeD) 是一种具有已知的全身影响的自身免疫性疾病.
- 新出现的证据表明,CeD和心血管并发症之间存在联系.
- 与CeD相关的心血管风险背后的确切机制仍然不完全理解.
研究的目的:
- 在一个人性化的小鼠模型中研究乳病对心血管的影响.
- 探索血管炎症,内皮功能障碍和氧化应激在CeD相关心血管变化中的作用.
- 为了确定肠道炎症和心血管病理之间的潜在分子联系.
主要方法:
- 在NOD.DQ8小鼠中,基因易患CeD,通过高质饮食诱导了该疾病.
- 在各种组织中评估了血管功能,疾病指标,炎症和氧化应激.
- 进行了等离子体蛋白质组分析,以确定分子介质.
主要成果:
- 在CeD小鼠中,质暴露导致血压升高和血管放松受损.
- 在主动脉和心脏中观察到促炎基因的升级,髓状细胞透和氧化应激.
- 血蛋白质组学确定了IN-17A (IL-17A) 作为肠道和血管炎症之间的潜在联系.
结论:
- 活跃的胰腺疾病与通过肠心血管炎症轴的心血管风险增加有关,可能涉及IL-17A.
- 在CeD小鼠中,心血管并发症在采用无质饮食后是可逆的.
- 这些发现强调了饮食干预在控制乳病中心血管风险方面的关键作用.
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