全免疫-炎症值预测延迟的脑缺血症在患有动脉瘤下arachnoid 出血的患者
Woonghee Han1, Ho Jun Yi2, Dong-Seong Shin1
1Department of Neurosurgery, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
概括
全免疫-炎症值 (PIV) 有效预测延迟脑缺血症 (DCI) 后动脉瘤下arachnoid出血 (aSAH). 升高的PIV水平表明这些患者患有DCI的风险更高.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 动脉瘤下arachnoid出血 (aSAH) 经常导致晚期大脑缺血症 (DCI).
- 炎症反应和免疫失调是DCI发病的关键因素.
- 早期DCI预测需要新的炎症标志物.
研究的目的:
- 评估泛免疫炎症值 (PIV) 作为aSAH后DCI的预测标记.
- 为了确定诊断准确度和PIV在预测DCI中的最佳切线.
主要方法:
- 分析了一组1028名aSAH患者的队列.
- 在入院时测量了包括PIV在内的外周血液炎症标志物.
- 采用了接收器操作特征 (ROC) 分析和多变量逻辑回归.
主要成果:
- 在患有DCI的患者中,与没有DCI的患者相比,PIV的平均值显著更高 (437.6对242.1,P=0.007).
- 在ROC分析中,发现DCI预测的最佳PIV切线为356.7 (AUC=0.772,P<0.001).
- 升高的PIV (≥356.7) 是DCI的独立预测因子 (OR=1.42,P=0.013),与高的亨特-赫斯等级和厚度下关节出血一起.
结论:
- 全免疫炎症值 (PIV) 是aSAH患者中DCI的强大和独立预测指标.
- 升高的PIV水平与增加的DCI发展有显著的关联.
- 在动脉瘤下arachnoid出血后,PIV为DCI提供了有价值的预测实用.
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