外化多基因分数与外化疾病的关联在墨西哥青年中
Gabriela A Martínez-Levy1, Mateo Maya-Martínez2, Luis M García-Marín3
1Departamento de Genética, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñíz", Ciudad de México, Mexico.
Journal of psychiatric research
|February 14, 2024
概括
对外化行为的遗传倾向与墨西哥青少年外化障碍和注意力缺陷多动症 (ADHD) 的更高几率有关. 这项研究突出了不同人群中的遗传关联.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 青少年健康 青少年健康
背景情况:
- 外化多基因分数 (PGS) 的关联主要研究于欧洲祖先.
- 有限的研究存在于对非欧洲青年,如墨西哥青少年的PGS外化.
- 了解跨祖先的遗传脆弱性对于公平的心理健康研究至关重要.
研究的目的:
- 检查外化PGS与墨西哥青少年外化障碍的关联.
- 研究童年逆境对这些遗传关联的缓和作用.
- 将对外化行为遗传倾向的发现扩展到多样化的人口中.
主要方法:
- 利用PGS来自欧洲祖先的大型全基因组关联研究数据集.
- 评估了1064名墨西哥青少年 (12-17岁) 的外部化障碍 (ADHD,行为障碍,反对性挑障碍,物质使用障碍) 和童年逆境.
- 雇佣了世界心理健康综合国际诊断面试,用于青少年的评估.
主要成果:
- 在总体样本中,更高的外化PGS与任何外化障碍 (OR=1.29) 和ADHD (OR=1.40) 的概率增加有显著的相关性.
- 这些关联在女性中尤为明显.
- 对于行为障碍,反对性挑性障碍或物质使用障碍,没有发现任何显著的关联,童年逆境也没有缓解任何关联.
结论:
- 对外化障碍的更大遗传倾向与墨西哥青少年普遍外化障碍和ADHD的几率增加有关.
- 这些发现有助于理解不同种族群体中外化障碍的表现.
- 表明PGS在识别不同祖先的风险青年方面具有潜在的实用性.
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