瘤透皮质参与大规模的认知电路
Ayan S Mandal1, Chemda Wiener2, Moataz Assem3
1Brain-Gene Development Lab, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, USA; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK.
概括
扩散性质瘤透到大脑组织中,但其在认知功能中的作用尚不清楚. 这项研究表明瘤透皮质参与执行功能网络,将连接性与患者的结果联系起来.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 在瘤学瘤学.
背景情况:
- 瘤透的大脑组织对认知功能的贡献尚未得到充分理解.
- 扩散性质瘤经常透到对认知至关重要的皮质区域.
研究的目的:
- 为了调查瘤透的皮质组织是否参与大规模的认知电路.
- 评估透组织的功能连接性与认知结果之间的关系.
主要方法:
- 结合内电皮图 (ECoG) 和静止状态功能磁共振成像 (fMRI).
- 在认知任务期间评估与任务相关的高玛功率调制.
- 分析了功能连接模式与正规的大脑网络.
主要成果:
- 瘤透皮质显示功能保留,在执行功能任务期间显著高玛功率调节.
- 任务响应区域与执行职能网络,特别是背部注意网络 (DAN) 具有功能连接性.
- 瘤-DAN连接性与目标导向注意力的长期术后结果相关.
结论:
- 瘤透皮质积极参与大规模的神经认知电路,支持执行功能.
- 绘制透组织的功能连接的地图可能在治疗扩散性质瘤方面具有临床实用性.
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