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相关概念视频

Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

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Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.6K
Classification of Leukocytes01:30

Classification of Leukocytes

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Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
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Inflammation01:38

Inflammation

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Overview
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Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

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An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
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相关实验视频

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Isolation and Characterization of Neutrophils with Anti-Tumor Properties
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中性粒细胞迫切需要专业化.

Carlos H Hiroki1, Bryan G Yipp1

  • 1Department of Critical Care, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Immunity
|February 14, 2024
PubMed
概括

中性粒细胞的两极分化对宿主防御至关重要,由神经NPFF及其受体MrgprA1.1指导. 这一发现澄清了影响肺炎易感性的机制.

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 神经科学是一个神经科学.

背景情况:

  • 中性粒细胞是具有多种功能的关键免疫细胞.
  • 控制中性粒细胞两极分化的机制尚未完全理解.
  • 中性粒细胞的两极分化影响免疫反应和疾病的结果.

研究的目的:

  • 研究调节中性粒细胞两极分化的分子机制.
  • 为了确定中性粒细胞功能在宿主防御中的新型调节者.
  • 探索GPCRs和神经在中性粒细胞两极化中的作用.

主要方法:

  • 利用遗传模型和分子生物学技术.
  • 研究了GPCR MrgprA1和神经NPFF的功能.
  • 评估了中性粒细胞的两极分化和迁移在体外和体内.
  • 评估了对宿主防御细菌感染的影响.

主要成果:

  • 证明GPCR MrgprA1和神经NPFF直接调节中性粒细胞的两极分化.
  • 展示了这个轴在控制中性粒细胞迁移和功能中的作用.
  • 与中性粒细胞两极分化与宿主防御机制和肺炎易感性有关.

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Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro
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Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

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结论:

  • 神经NPFF及其受体MrgprA1是中性粒细胞两极分化的关键调节者.
  • 这一途径影响免疫细胞贩运和宿主防御.
  • 针对这一轴可能为管理肺炎和其他炎症状况提供新的策略.