前带带皮层向背部中间条纹体的投射是与慢性疼痛相关的不眠症的基础
Ya-Dong Li1, Yan-Jia Luo2, Wei-Kun Su3
1Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Joint International Research Laboratory of Sleep, and Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Songjiang Research Institute, Songjiang Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai 201699, China.
前环状皮层 (ACC) 中的过度活跃的神经元会在慢性疼痛中引起失眠. 这个大脑电路功能障碍,特别是ACC.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 睡眠科学 睡眠科学
背景情况:
- 慢性疼痛经常导致睡眠障碍,但基本的神经机制尚不清楚.
- 确定与疼痛相关的失眠有关的特定大脑电路对于开发向疗法至关重要.
研究的目的:
- 为了研究前带状皮层 (ACC) 金字塔神经元 (PNs) 在慢性疼痛引起的失眠中的作用.
- 阐明通过ACC过度活跃导致睡眠障碍的神经电路路径.
主要方法:
- 利用神经损伤引起的慢性疼痛的小鼠模型.
- 采用光遗传学和电生理学记录来评估神经元活动和突触可塑性.
- 测量了ACC中的神经元活动及其投射到背部中间条纹体 (DMS).
主要成果:
- 在慢性疼痛模型中,在失眠期间观察到ACCPN的自发性过度活跃.
- ACC PN 过度活跃是诱导失眠的必要和充分因素.
- 通过多巴胺D1R神经元中增强的突触活动和可塑性,ACC投射到DMS调解了失眠.
结论:
- ACC金字塔神经元的过度活跃是慢性疼痛中失眠的关键驱动因素.
- ACC-DMS通路在与疼痛相关的睡眠障碍的病理生理学中发挥着关键作用.
- 准ACC电路可能为慢性疼痛和相关失眠提供新的治疗策略.
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