大脑年龄,大脑健康和精神障碍:一个系统的审查
Johanna Seitz-Holland1, Shalaila S Haas2, Nora Penzel3
1Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
大脑衰老指标BrainAGE在神经精神疾病中升高,但需要进一步验证. 目前的研究表明有希望,但缺乏多样化的数据和外部验证来确认其作为可靠的生物年龄标志物的作用.
科学领域:
- 神经成像是一种神经成像.
- 神经精神病学是一种神经精神病学.
- 衰老研究研究 衰老研究
背景情况:
- 脑AGE成像方法评估了与年龄相关的大脑变化的脆弱性.
- 神经精神疾病越来越多地研究它们对大脑衰老的影响.
- 了解生物年龄标志物对于临床应用至关重要.
结论:
- 虽然brainAGE检测到群体差异,但其作为生物年龄标志物的有效性有限.
- 局限性包括缺乏多样化的培训样本,多模式数据和外部验证.
- 未来的研究需要纵向数据和算法超越时间年龄预测强大的生物年龄评估.
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