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SB-258585降低了食物的动机,同时阻断了非人类灵长类动物状体中的5-HT6受体

Mathilde Pitoy¹, Lisa Gauthier², Justine Debatisse³

¹Institut des Sciences Cognitives Marc Jeannerod, UMR-5229 CNRS, 67 boulevard Pinel, 69675 Bron Cedex, France; Université Claude-Bernard Lyon1, 69100 Villeurbanne, France; Hospices Civils de Lyon, 3 Quai des Célestins, 69002 Lyon, France.

Progress in neuro-psychopharmacology & biological psychiatry

|February 14, 2024

概括

在中选择性5-HT6受体阻断显著降低了食物动机,主要通过条状通路起作用. 这一发现在灵长类动物中是新鲜的,支持潜在的肥胖治疗方法,但质疑抗焦虑效应.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
灵长类动物的行为

背景情况:

5-HT6受体剂调节认知,食物动机和焦虑,主要研究在动物身上.
有限的研究存在于灵长类动物的5-HT6受体功能和大脑局部.
条形体,富含5-HT6受体,涉及到有动机的行为.

研究的目的:

研究5-HT6受体对抗作用对非人类灵长类动物的食物动机和行为的影响.
为了确定由5-HT6受体对抗剂准的大脑区域,特别是条纹子区域.
探索5-HT6受体对抗剂在治疗肥胖和焦虑方面的潜力.

主要方法:

选择性5-HT6受体抗剂 (SB-258585) 的急性给予六只雄性.
使用食物选择任务和行为观察评估养动机.
用[18F]2FNQ1P进行正子发射断层扫描 (PET) 成像,以测量5-HT6受体占用率.

主要成果:

5-HT6受体对抗性显著降低了非人类灵长类动物的食物动机.
确定了包括膜和尾状核在内的状子区域作为关键目标.
与对食物动机的影响相比,行为影响是可变的,并且不那么明显.

结论:

状体5-HT6受体调节是影响灵长类动物食物动机的关键机制.
这些发现支持在肥胖管理中使用5-HT6受体对抗剂的潜在治疗用途.
这些对抗剂的抗焦虑作用需要进一步调查,因为结果不那么有说服力.

关键词:

5-HT6受体的受体是什么?焦虑行为焦虑行为.食物动机食物的动机非人类灵长类的灵长类.在PET成像中使用PET成像.状体是一个状体.

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