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相关概念视频

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

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The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
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Diencephalon: Hypothalamus and Coordination01:23

Diencephalon: Hypothalamus and Coordination

1.5K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
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Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

1.9K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
1.9K
Association Areas of the Cortex01:21

Association Areas of the Cortex

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Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
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Neurotransmitters01:31

Neurotransmitters

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Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
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Brainstem01:19

Brainstem

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The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
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相关实验视频

Updated: Jul 3, 2025

Fluorescence Activated Cell Sorting FACS and Gene Expression Analysis of Fos-expressing Neurons from Fresh and Frozen Rat Brain Tissue
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Fluorescence Activated Cell Sorting FACS and Gene Expression Analysis of Fos-expressing Neurons from Fresh and Frozen Rat Brain Tissue

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需要Foxp2来实现核Accumbens介导的多方面的边缘功能.

Bo-Han He1, Ya-Hui Yang1, Bo-Wen Hsiao1

  • 1Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.

Neuroscience
|February 14, 2024
PubMed
概括

叉子盒蛋白P2 (Foxp2) 调节成年老鼠大脑中的边缘功能. 在核 (NAc) 中Foxp2的有条件淘汰会损害社会行为,奖励学习和恐惧反应.

关键词:
在Foxp2中使用.恐惧学习学习学习学习它的核心是accumbens的核心.奖励学习学习奖励学习社会互动 社交互动

更多相关视频

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
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Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

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A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents
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A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

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相关实验视频

Last Updated: Jul 3, 2025

Fluorescence Activated Cell Sorting FACS and Gene Expression Analysis of Fos-expressing Neurons from Fresh and Frozen Rat Brain Tissue
08:37

Fluorescence Activated Cell Sorting FACS and Gene Expression Analysis of Fos-expressing Neurons from Fresh and Frozen Rat Brain Tissue

Published on: August 27, 2016

29.3K
Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
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Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

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A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents
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科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 行为科学 行为科学

背景情况:

  • 叉子盒蛋白P2 (Foxp2) 对于神经发育至关重要,特别是语音和语言.
  • 它在成年人大脑生理学中的作用,特别是在核 (NAc) 中,尚不清楚.
  • 之前的研究集中在发育角色,留下了一个关于成人大脑功能知识的差距.

研究的目的:

  • 研究成年小鼠大脑NAc中Foxp2的生理功能.
  • 为了确定在NAc中Foxp2缺乏对边缘关联行为的影响.
  • 阐明Foxp2在社会新性,奖励学习和恐惧调节中的特定作用.

主要方法:

  • 使用AAV-EGFP-Cre微注射在Foxp2的小鼠中,在NAc中间中条件淘汰Foxp2.
  • 在NAc.中评估神经元活动 (c-Fos表达) 的免疫抑制.
  • 无偏见的行为分析,以评估社会新性,食欲奖励学习和恐惧学习/灭绝.

主要成果:

  • 在NAc中Foxp2缺乏导致基底c-Fos表达增加,表明神经元活动发生改变.
  • 福克斯p2 cKO小鼠表现出受损的社会新性,无法区分熟悉和新鲜的小鼠.
  • 在食欲奖励学习和恐惧调节中观察到异常,包括改变结反应和恐惧灭绝.

结论:

  • Foxp2在成年大脑的NAc中起着重要的生理作用.
  • 在NAc中的Foxp2对于调节社会行为,奖励学习和恐惧反应至关重要.
  • 在NAc中Foxp2的有条件淘汰不会影响运动,运动协调或类似焦虑的行为.