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相关概念视频

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

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The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
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Chronic Pancreatitis II: Collaborative Care01:29

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Hepatic Drug Clearance: Role of Transporters01:14

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In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
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Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

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Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
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Hepatic Drug Excretion: Influencing Factors01:16

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The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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隐藏性肝病:一个跨国视角

Paulina Vidal-Cevallos1, Nayelli Flores-García2, Norberto C Chávez-Tapia1

  • 1Obesity and Digestive Disease Unit, Medica Sur Clinic and Foundation, Puente de Piedra 150, Toriello Guerra, 14050, Mexico City, Mexico.

Annals of hepatology
|February 14, 2024
PubMed
概括

隐藏性肝病,往往没有被认可,是全球重要的健康问题. 早期查和治疗,特别是非酒精性脂肪肝 (NAFLD) 和病毒性肝炎,对于降低死亡率至关重要.

关键词:
酒精性肝病是一种肝病.肝硬化是肝硬化的一种.流行病学 流行病学拉丁美洲 拉丁美洲 拉丁美洲非酒精性脂肪性肝病是非酒精性脂肪性肝病.病毒性肝炎的病毒性肝炎.

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科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 公共卫生 公共卫生
  • 流行病学 流行病学

背景情况:

  • 肝病是全球第11大死亡原因,占所有死亡人数的4%.
  • 酒精消费是肝硬化的主要驱动因素 (60%的病例),而非酒精性脂肪肝 (NAFLD) 患病率在全球上升 (估计为32.4%).
  • 病毒性乙型肝炎和型肝炎在2020年造成了130万人的死亡,突显了传染性肝病的负担.

研究的目的:

  • 为了强调隐藏性肝病的意义,定义为未被认可的慢性肝病和肝硬化.
  • 突出需要评估拉丁美洲隐性肝病的流行率,该地区的代谢疾病和酒精消费率很高.
  • 倡导针对性查和肝病早期干预策略.

主要方法:

  • 全球肝病统计和风险因素的综述.
  • 识别隐性肝病的高风险人群,包括肝酶升高,2型糖尿病和过度饮酒的人群.
  • 强调对非酒精性脂肪性肝病 (NAFLD) 和酒精使用障碍的查策略.

主要成果:

  • 研究表明,风险人群中隐性肝病的患病率很高.
  • 拉丁美洲是需要进一步调查的关键地区,因为其代谢疾病和酒精消费率很高.
  • 早期检测和干预是减轻肝病负担的关键.

结论:

  • 隐藏性肝病在全球范围内代表着相当大的,往往未被发现的健康负担.
  • 在高风险人群中,针对NAFLD和与酒精有关的肝病进行有针对性的查至关重要.
  • 及时治疗隐性肝病,包括病毒性肝炎,可以预防进展和传播,降低整体死亡率.