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回复阿里·谢安法尔博士的评论.

Han Hao1, Jing Wang1

  • 1School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, People's Republic of China.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
|February 14, 2024
PubMed
概括
此摘要是机器生成的。

这项研究阐明了5-甲 (5-FU) 和酸 (GA) 的共晶形成. 5-FU-GA共晶体显示了独立于5-FU可溶性的增强细胞毒性,稳定性分析证实了这一点.

关键词:
5 - - 甲酸是一种甲.在Cocrystal中使用.细胞毒性 细胞毒性酸是一种酸.可溶性 溶解度 溶解度 溶解度

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科学领域:

  • 制药科学 制药科学
  • 晶体工程公司 晶体工程
  • 药物运输 药物运输 药物运输

背景情况:

  • 同结晶是改善药物特性的一个关键策略.
  • 5-甲 (5-FU) 是一种广泛使用的化疗剂.
  • 酸 (GA) 已经显示出作为制药共晶体的共同制剂的潜力.

研究的目的:

  • 解决关于5-甲 (5-FU) 和酸 (GA) 的联合结晶的澄清问题.
  • 讨论5-FU-GA共晶体的可溶性,生物活性和稳定性.
  • 为了澄清有关细胞毒性测定方法的误解.

主要方法:

  • 用于固态特性和稳定性评估的X射线衍射 (XRD) 分析.
  • 可溶性测定实验. 试验中的可溶性.
  • 细胞毒性测试.细胞毒性测试.

主要成果:

  • 在溶解度测量过程中,5-FU-GA共晶体的稳定性通过XRD得到证实.
  • 发现5-FU-GA共晶体的增强细胞毒性独立于5-FU溶解度.
  • 提供了关于细胞毒性测试的方法澄清.

结论:

  • 在溶性测试条件下,5-FU-GA共晶是稳定的.
  • 观察到的细胞毒性增加是共晶的内在性质,不仅仅是由于5-FU可溶性增加.
  • 这项工作支持了之前关于5-FU-GA共晶体治疗潜力的发现.