使用Lecythis pisonis种子的副产品开发天然化品乳液
Danielle Braga Portes1, Lucas Wetler Abeldt1, Cristiane Dos Santos Giuberti2
1Pharmaceutical Science Graduate Program, Vila Velha University, Vila Velha, ES, Brazil.
概括
沙普卡亚种子提取物是一种天然化品成分,在安全性评估中没有表现出细胞毒性,并且不刺激. 这种可持续的副产品显示出在天然化品乳液中安全局部使用的潜力.
科学领域:
- 化品科学 化品科学
- 自然产品 化学 化学
- 皮肤病学 皮肤病学
背景情况:
- 由于可持续性和生物多样性意识,人们对化品中的天然产品越来越感兴趣.
- 探索植物副产品作为化品成分的有价值来源.
- 化品行业需要安全有效的天然成分.
研究的目的:
- 使用Lecythis pisonis (sapucaia) 种子贝提取物开发一种天然的化品乳液.
- 为了评估sapucaia种子提取物局部应用的安全性.
- 评估化品配方中防腐剂系统的稳定性和有效性.
主要方法:
- 使用MTT测定对L929纤维细胞,HaCat角质细胞和EA.hy926内皮细胞进行细胞毒性评估.
- 在体外刺激试验包括HET-CAM,CAM-TBS和血液溶解 (RBC) 试验.
- 对常见的细菌和真菌进行微生物挑战测试 (大肠杆菌,P. aeruginosa,S. aureus,C. albicans,A. niger).
主要成果:
- 原始沙普卡亚种子提取物没有表现出细胞毒性,IC50指数>780 mg/mL.
- 化品乳液配方根据体外测试被归类为无刺激性.
- 防腐剂系统有效地抑制了测试微生物的生长,确保了产品的安全性.
结论:
- 桑普卡亚种子 (Lecythis pisonis) 的副产品是天然化品乳液的可行和安全成分.
- 开发的含有提取物的化品配方是安全的局部使用.
- 植物副产品的可持续利用可以导致创新和安全的化品.
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