Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Replisome03:01

The Replisome

33.5K
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
33.5K
DNA as a Genetic Template02:05

DNA as a Genetic Template

21.9K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
21.9K
DNA Packaging00:58

DNA Packaging

102.5K
Overview
102.5K
The DNA Replication Fork01:02

The DNA Replication Fork

36.0K
An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
36.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Programming Dimensional Transitions in DNA Brick Crystals via Interfacial Connectivity.

Angewandte Chemie (International ed. in English)·2026
Same author

Spatial Engineering of Gas Diffusion Layers Overcomes Mass Transport Limitations in Fuel Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Structure-Controlled Molecular Recognition and Charge Transport in Metallized DNA Nanosheets.

Journal of the American Chemical Society·2026
Same author

Author Correction: Atomically precise photothermal nanomachines.

Nature materials·2026
Same author

L-DNA-Based Framework Nucleic Acid Nanodevice for Lysosomal ATP Imaging.

Analytical chemistry·2026
Same author

DNA-Programmed Amorphous PtCu Nanohybrids With Spatially Partitioned Functions for Hydrogen Evolution.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

A Ni-Mediated Cross-Coupling Approach to Deuterated <sup>18</sup>F- Fluoromethylated (Hetero)arenes.

Journal of the American Chemical Society·2026
Same journal

Efficient Light-Driven CO<sub>2</sub> Capture and Reversible Release Enabled by Metastable Photoacid-Decorated Metal-Organic Frameworks.

Journal of the American Chemical Society·2026
Same journal

In Situ Raman Spectroscopy Reveals the Dynamic Evolution and Ethanol Dependence of SEI Structure in Li-Mediated N<sub>2</sub> Reduction Reaction.

Journal of the American Chemical Society·2026
Same journal

Solvent Esterification and Stoichiometric Control in Ambient-Grown FAPbI<sub>3</sub> Single-Crystal Solar Cells.

Journal of the American Chemical Society·2026
Same journal

Unlocking Azulene Functionalization via Strain-Induced Azulyne Intermediates.

Journal of the American Chemical Society·2026
Same journal

An Oxazine-Locked Covalent Organic Framework by a Tandem Pinner/Schiff Base Reaction for Hydrogen Peroxide Photosynthesis.

Journal of the American Chemical Society·2026
查看所有相关文章

相关实验视频

Updated: Jul 3, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.7K

空间编程的二维DNA原始组件

Yongjun Liu1, Zheze Dai1, Xiaodong Xie1

  • 1School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhangjiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.

Journal of the American Chemical Society
|February 14, 2024
PubMed
概括
此摘要是机器生成的。

编程DNA间隔器的长度可以精确地控制DNA原形组装. 这种方法提高了杂交效率和模式多样性,为复杂的纳米结构实现了高产量.

更多相关视频

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.3K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.1K

相关实验视频

Last Updated: Jul 3, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.7K
Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

22.3K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.1K

科学领域:

  • 纳米技术
  • 生物分子工程
  • 材料科学

背景情况:

  • 两维 (2D) DNA 原形组装是创建先进的二维材料的关键方法.
  • DNA间隔器是混合介导的 2D DNA 原形组件中的关键连接器,影响单元结合.

研究的目的:

  • 研究编程DNA间隔长度如何影响粘性结尾杂交和2DDNA原形阵列的组装.
  • 优化DNA原始结构的组装效率和模式多样性.

主要方法:

  • 使用DNA-PAINT超分辨率成像来分析杂交效率.
  • 使用分子动力学模拟来研究间隔器长度和热力学波动之间的相关性.
  • 编程DNA间隔长度来控制DNA原形单位的结合半径.

主要成果:

  • 间隔器长度在正方形DNA原形 (SDO) 单元组件中显著影响粘性末端杂交效率.
  • 组装效率和模式多样性严重依赖于编程的间隔器长度.
  • 通过使用间隔器编程策略实现SDO三元体和四元体组装的高产量 (∼98%).

结论:

  • 间隔器长度是精确控制二维DNA原型组件的关键参数.
  • 这一策略使得高效率的多样化和复杂的DNA纳米结构能够产生.
  • 这些发现有助于精确组装DNA纳米结构,