在COVID-19疫苗接种后的双边非动脉炎后部缺血性视神经病变
Dominique Salh1, Ashlyn Pinto2, Paul Freund3
1Ophthalmology and Visual Sciences, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada dominiquesalh@dal.ca.
BMJ case reports
|February 14, 2024
概括
本案例研究详细介绍了ChAdOx1 nCoV-19疫苗接种后一名男子的视力损失. 诊断出双边后部缺血性视神经病变,这种情况以前与此COVID-19疫苗无关.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 接种COVID-19疫苗对公共健康至关重要.
- 免疫接种后的不良事件需要彻底调查.
- 缺血性视神经病变 (ION) 是一种严重影响视力的疾病.
研究的目的:
- 报告一种罕见的双边后部缺血视神经病变 (ION) 病例.
- 调查ChAdOx1 nCoV-19疫苗与ION之间的潜在关联.
- 为了解与疫苗有关的神经系统并发症做出贡献.
主要方法:
- 一个病人的病例报告呈现急性双侧视力丧失.
- 临床评估包括视力敏度,神经学检查和实验室测试.
- 用扩散权重MRI进行诊断成像,以评估视神经.
- 对类似报告病例的现有文献的审查.
主要成果:
- 一名60多岁的男子在ChAdOx1 nCoV-19疫苗接种10天后出现双边急性视力丧失.
- 视力敏度在双边严重受损 (计数手指).
- 核磁共振扫描显示,沿着两只视神经的扩散受限,与缺血性视神经病变一致.
- 标准的血液检测和血清检测感染和自身免疫性疾病是负的.
- 报告没有先前的视觉症状或巨细胞动脉炎的迹象.
- 患者的视力在5个月后仍然严重受损,视神经白.
结论:
- 这是ChAdOx1 nCoV-19疫苗接种后首次报告单独的双边后部缺血性视神经病变的病例.
- 时间关联表明疫苗和ION的发展之间存在潜在的,尽管未被证明的联系.
- 需要进一步的研究和监测来确定因果关系并了解相关机制.
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