南亚成年人的血管再生细胞缺陷
Aishwarya Krishnaraj1, Ehab Bakbak1, Hwee Teoh2
1Division of Cardiac Surgery, St Michael's Hospital of Unity Health Toronto, Toronto, Ontario, Canada; Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
Journal of the American College of Cardiology
|February 14, 2024
概括
患有心脏代谢疾病的南亚人具有较少的血管再生细胞,这表明血管修复可能受损. 这一发现可能解释了在这个人群中观察到的较高的血管风险.
科学领域:
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
- 再生医学是一种再生医学.
背景情况:
- 南亚人群在心脏代谢疾病的发生率不成比例地高.
- 了解这种差异的生物学基础对于有针对性的干预至关重要.
研究的目的:
- 研究南亚和白人欧洲人之间血管再生细胞含量的差异.
- 确定这些细胞中的种族变异是否与血管风险增加相关.
主要方法:
- 预计将招募60名南亚裔和60名白人欧洲成年人,这些成年人患有心血管疾病或糖尿病以及危险因素.
- 使用基于脱酶 (ALDH) 活性和细胞表面标记物的流动细胞计量,在血液中计数血管再生细胞.
- 主要结局:种族之间循环中的高ALDH原生细胞,单细胞和粒细胞的差异.
主要成果:
- 与白人欧洲人相比,南亚参与者更年轻,患2型糖尿病的患病率更高,但体重较低.
- 在南亚人中发现的亲血管性ALDH高前代细胞 (ALDHhiSSClowCD133+) 和血管修复单细胞 (ALDHhiSSCmidCD14+CD163+) 的频率明显较低.
- 在调整了临床因素后,南亚族裔独立地与较低的ALDHhiSSClowCD133+细胞数量有关.
结论:
- 患有心脏代谢疾病的南亚人表现出降低了血管再生和修复细胞的水平.
- 这些细胞差异表明血管修复能力受到损害,可能导致这一人口群体血管风险升高.
- 这项研究强调了在细胞水平上血管健康的潜在种族差异.
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