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Updated: Jul 3, 2025

Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay
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Measuring Enzymatic Activity of Neurodevelopmental Disorder-Associated Deubiquitylating Enzymes via an In Vitro Ubiquitin Chain Cleavage Assay

Published on: September 27, 2024

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在USP deubiquitinase催化机制中的多样性

Niels Keijzer1, Anu Priyanka1, Yvette Stijf-Bultsma1

  • 1Division of Biochemistry and Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands.

Life science alliance
|February 14, 2024
PubMed
概括

无处不在特异蛋白酶 (USP) 家族具有多样化的催化机制,其中一些依赖于关键残留物,而另一些则依赖于相邻的残留物. 这一发现为开发有针对性的USP疗法提供了新的途径.

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