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The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
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[转移的鼻腔瘤]

Charles Lépine1, Aude Trinquet2, Marick Laé3

  • 1Service d'anatomie et cytologie pathologiques, Nantes université, CHU de Nantes, 44000 Nantes, France; Inserm, CNRS, Immunology and New Concepts in ImmunoTherapy (INCIT), UMR 1302/EMR6001, Nantes, France.

Annales de pathologie
|February 14, 2024
PubMed
概括

这项研究审查了具有特定基因融合的鼻腔和鼻腔瘤,包括DEK::AFF2状细胞癌和具有EWSR1::FLI1重组的肉瘤. 它详细介绍了它们的形态学,免疫组织化学和预后.

关键词:
癌瘤的癌症是什么癌症组 癌症组 癌症组化石的鼻腔部分.鼻腔中的鼻腔.调整的重新安排重组的重新安排.这种类型的肉瘤是sarcoma.萨尔科梅 (Sarcome Sarcome) 是一种类型的药物.鼻腔 鼻腔是一个神经系统.

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科学领域:

  • 在瘤学瘤学.
  • 遗传学 是一个遗传学.
  • 病理学 病理学 病理学

背景情况:

  • 鼻腔和鼻腔瘤可以表现出特定的遗传重组.
  • 融合基因在各种瘤实体中越来越多地被发现.
  • 在鼻区域的辅助唾液腺可以引起瘤.

研究的目的:

  • 用于描述由特定基因融合特征的鼻腔实体.
  • 为这些实体提供形态学,免疫组织化学和预后细节.
  • 突出基因变化的作用在鼻瘤分类中的作用.

主要方法:

  • 对基因融合的鼻腔瘤的文献综述.
  • 描述实体的形态和免疫组织化学分析.
  • 遗传发现与临床和预后数据的相关性.

主要成果:

  • DEK::AFF2 发现了状细胞癌.
  • 讨论了与ETV6重组的非肠道和非唾液鼻腺癌.
  • 两种类型的鼻类瘤 (PAX3重组) 和欧文的亚达曼瘤类瘤 (EWSR1::FLI1重组) 具有特征.

结论:

  • 特定的基因融合是鼻瘤的关键诊断和预后标志物.
  • 准确的分类需要整合形态,免疫组织化学和分子数据.
  • 了解这些遗传变异有助于向治疗和改善患者的治疗结果.