血清纤维细胞生长因子-2水平补充了诊断心力衰竭的重要生物标志物
1Department of Pharmacy, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
BMC cardiovascular disorders
|February 14, 2024
概括
纤维细胞生长因子-2 (FGF2) 在心力衰竭患者中显示出高水平,使其与健康个体区别开来. 这一发现表明FGF2是诊断心力衰竭和评估其严重程度的有价值生物标志物.
科学领域:
- 心脏病学 心脏病学
- 生物标志物发现发现
- 心脏衰竭诊断 心脏衰竭的诊断
背景情况:
- 对心房的早期诊断对于患者的治疗结果至关重要.
- 纤维细胞生长因子-2 (FGF2) 涉及心脏纤维化和缩,但其在心力衰竭诊断中的作用尚不清楚.
- 这项研究调查了FGF2作为一种潜在的生物标志物,以区分心力衰竭患者.
研究的目的:
- 确定FGF2水平是否可以区分心力衰竭患者与对照患者以及非心力衰竭呼吸障碍患者.
- 评估血清FGF2水平与心力衰竭预后参数之间的相关性.
主要方法:
- 血FGF2度测定在114名呼吸障碍患者中.
- 患者被分为心力衰竭 (n=80),非心力衰竭呼吸障碍 (n=34) 和健康对照 (n=36) 组.
- 分析了血清FGF2和预后标志物之间的相关性.
主要成果:
- 心力衰竭患者的血清FGF2水平明显高于非心力衰竭呼吸障碍患者和健康对照患者 (p < 0.001).
- 接收器操作特征分析显示,FGF2是心力衰竭的重要预测因子 (AUC = 0.8693,p < 0.0001).
- FGF2度与左心室喷射分数减少和N-终端增高的B型亲尿素相关.
结论:
- 血清FGF2水平升高与心力衰竭风险增加密切相关.
- FGF2可以作为一个有价值的生物标志物来补充心力衰竭的现有诊断参数.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
92
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
92
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
156
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
156
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
106
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
106
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K