了解系统化疗和放射治疗后乳腺癌患者肺功能和功能状况的变化:一项前性研究
Alper Tuğral1, Zeynep Arıbaş2, Murat Akyol3
1Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Izmir Bakırçay University, Izmir, Turkey. alper.tugral@bakircay.edu.tr.
BMC pulmonary medicine
|February 14, 2024
概括
化疗和放射治疗显著降低乳腺癌患者的肺功能,减少1秒内强迫生命能力 (FVC) 和强迫呼吸量 (FEV1). 在整个治疗过程中,持续的呼吸监测至关重要.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 辐射疗法 辐射疗法
背景情况:
- 接受化疗 (CT) 和放射治疗 (RT) 的乳腺癌 (BC) 患者容易发生呼吸道并发症.
- 调查这些并发症对于预防次要问题和改善患者的治疗结果至关重要.
研究的目的:
- 评估全身化疗和放射治疗对乳腺癌患者呼吸功能和功能状态的急性影响.
主要方法:
- 25名乳腺癌患者使用肺功能测试 (PFT) 和六分钟步行测试 (6MWT) 进行了评估.
- 评估是在CT (c0) 之前,CT (c1) 之后,以及RT (r1) 之后进行的.
主要成果:
- 在CT后,强迫生命能力 (FVC) 和1s强迫呼吸量 (FEV1) 显著下降.
- 呼吸道肌肉强度 (MIP,MEP) 在CT后没有显著变化.
- 观察到手术类型对FVC的显著影响,整体FVC从基线到后RT显著下降.
结论:
- 化疗和放射治疗导致乳腺癌患者的FVC和FEV1减少.
- 年龄和手术类型等临床因素会影响早期呼吸系统的变化.
- 在整个治疗过程中,建议持续监测呼吸功能.
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