通过KDM6A对CD38/CD48的表观遗传调节调解了多发性髓瘤中NK细胞的反应

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Jiye Liu1, Lijie Xing2, Jiang Li3

  • 1Jerome Lipper Multiple Myeloma Center, Lebow Institute for Myeloma Therapeutics, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.

Nature communications
|February 14, 2024
PubMed
概括

在多发性骨髓瘤中,KDM6A的损失会通过降低CD38.8的调节,导致对达拉图马布治疗的耐药性. EZH2 抑制剂可以恢复敏感性,为多发性骨髓瘤患者提供新的治疗策略.

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