在延长BNT162b2b2的剂量间隔后,青少年患心脏炎的风险较大
Min Fan1, Kuan Peng2, Yin Zhang2
1Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, China.
NPJ vaccines
|February 14, 2024
概括
延长COVID-19疫苗剂量之间的间隔显著降低了青少年心脏炎的风险. 这项研究表明,在接受第二剂BNT162b2剂后56天或更长时间后,接受第二剂BNT162b2剂的人的风险降低了66%.
科学领域:
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
- 青少年健康 青少年健康
背景情况:
- 使者RNACOVID-19疫苗已与青少年心脏炎风险增加有关.
- 一些地区延长了疫苗剂量之间的间隔,以减轻这种风险,但证据有限.
研究的目的:
- 评估延长BNT162b2COVID-19疫苗剂量间隔的有效性,以减少青少年心脏炎风险.
- 为优化青少年疫苗接种策略提供证据.
主要方法:
- 一个嵌套的病例控制研究,使用香港全境电子健康记录 (2021年2月 - 2022年8月).
- 包括12-17岁的青少年,他们接受了两剂BNT162b2疫苗.
- 标准 (21-27天) 和延长 (≥56天) 剂量间隔之间的心脏炎风险比较.
主要成果:
- 第二剂后28天内心炎的累积发病率为每百万分之37.41.
- 处方间隔时间长 (≥56天) 的青少年患心脏炎的风险显著降低 (调整后几率比:0.34).
- 对14天内心脏炎的敏感性分析也显示风险降低 (调整后的几率比:0.30).
结论:
- 将BNT162b2疫苗的剂量间隔延长到56天或更长时间,与青少年心脏炎风险降低66%有关.
- 研究结果支持基于证据的疫苗接种策略和青少年群体潜在的产品标签更新.
- 这项研究为公共卫生政策提供了关于青少年mRNACOVID-19疫苗接种的关键数据.
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