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分子成像方法在预测从轻度认知障碍到痴呆症的进展方面的诊断性能:更新的系统性审查

Matteo Cotta Ramusino¹, Federico Massa^2,3, Cristina Festari⁴

¹Unit of Behavior Neurology and Dementia Research Center, IRCCS Mondino Foundation, via Mondino 2, 27100, Pavia, Italy. matteo.cottaramusino01@universitadipavia.it.

European journal of nuclear medicine and molecular imaging

|February 14, 2024

概括

分子成像显示在预测阿尔茨海默氏症痴呆症从轻度认知障碍进展的准确度中等至良好. 然而,对于其他神经退行性疾病,纵向研究很少,需要进一步研究.

科学领域:

神经成像是一种神经成像.
生物标志物发现发现
神经退行性疾病神经退行性疾病

背景情况:

早期神经认知障碍分子成像生物标志物的临床验证受到流行病学和后勤挑战的阻碍.
本综述综合了分子成像技术近期 (2017-2022) 的进展,用于预测轻度认知障碍 (MCI) 的进展.
在现有研究中强调了现有研究的方法缺陷.

研究的目的:

系统地审查分子成像生物标志物的最新进展,以预测神经认知障碍的进展.
突出这些生物标志物的临床验证中的方法缺陷.

主要方法:

使用粉胺-PET,tau-PET,FDG-PET,DaT-SPECT和MIBG光学扫描的研究的系统审查.
研究包括≥50名MCI受试者,随访时间≥3年,进展为痴呆或病理,作为黄金标准.
使用PRISMA和QUADAS-2工具进行质量评估.

主要成果:

[18F]FDG-PET和粉胺-PET在预测阿尔茨海默氏症痴呆症进展方面表现出中等至良好的准确性.
在非阿尔茨海默氏症痴呆症中,对tau-PET,DaT-SPECT和MIBG光学扫描的纵向数据有限.
DaT-SPECT和MIBG光学扫描显示在区分勒维体病时具有可变的准确性.

结论:

分子成像为MCI向阿尔茨海默氏症痴呆症的进展提供了宝贵的见解.
对于较不常见的神经退行性疾病的纵向数据存在重大差距.
进一步的研究对于提高分子成像在各种痴呆症亚型中的临床实用性至关重要.

关键词:

粉样蛋白-PET 是一种这就是DaT-SPECT的特点.德国联邦财政部-PET MIBG心脏光学扫描仪的心脏扫描仪轻度认知障碍轻度认知障碍 -PET是一种PET.

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