吸烟会改变适应性免疫,并产生持久的影响
Violaine Saint-André1,2, Bruno Charbit3, Anne Biton4
1Translational Immunology Unit, Department of Immunology, Institut Pasteur, Université Paris Cité, Paris, France. violaine.saint-andre@pasteur.fr.
Nature
|February 14, 2024
概括
吸烟,细胞巨核病毒感染和体重指数显著影响免疫反应和细胞因子分泌. 吸烟情况
科学领域:
- 免疫学
- 人类生理学
- 遗传学
背景情况:
- 免疫反应的变异性受到年龄,性别和遗传学的影响.
- 驱动细胞因子分泌的差异,对于宿主防御至关重要,并未得到充分理解.
研究的目的:
- 确定导致细胞因子分泌的个体差异的关键变量.
- 研究吸烟对免疫反应的明显短期和长期影响.
主要方法:
- 对136个可能影响免疫反应的变量进行分析.
- 与各种因素相关的细胞因子分泌模式的评估.
- 调查与过去的吸烟相关的表观遗传修饰.
主要成果:
- 吸烟,细胞巨核病毒 (CMV) 隐藏感染和体重指数 (BMI) 被确定为细胞因子反应变异的主要因素,与年龄,性别和遗传学相比.
- 吸烟会影响先天性和适应性免疫;先天性反应效应在戒烟后是短暂的,与CEACAM6有关,而适应性效应则由于表观遗传记忆而持续存在.
- 过去的吸烟效应与信号激活器和代谢调节器中的DNA甲基化模式相关.
结论:
- 鉴定出吸烟,CMV感染和BMI是细胞因子分泌变异的重要因素.
- 吸烟在免疫反应中具有明显的短期和长期调节作用.
- 研究结果表明,对感染,癌症和自身免疫性疾病的风险有潜在的临床影响.
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