饮食中的酸含量和与肝硬化有关的死亡率:一项前性队列研究
Fereshteh Pashayee-Khamene1,2, Zeinab Heidari1, Danial Fotros2
1Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Scientific reports
|February 14, 2024
概括
饮食中的高酸负荷 (DAL) 与肝硬化患者的死亡率增加有关. 这项研究发现,较高的潜在酸负荷 (PRAL) 和净内源性酸产量 (NEAP) 评分显著增加了肝硬化相关的死亡风险.
科学领域:
- 胃肠病学和肝病学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 肝硬化是全球主要的健康问题,导致严重的发病率和死亡率.
- 了解饮食等可修改的风险因素对于管理肝硬化结果至关重要.
研究的目的:
- 调查饮食中的酸性负载 (DAL) 与肝硬化相关死亡率之间的关联.
- 评估潜在的酸负载 (PRAL) 和内源性酸净产量 (NEAP) 对新诊断的肝硬化患者死亡风险的影响.
主要方法:
- 一项前性队列研究,对121名新诊断的肝硬化患者进行了48个月的随访.
- 使用基于饮食摄入量评估的PRAL和NEAP分数估计的食酸负荷.
- 考克斯比例危险分析用于计算危险比率 (HR) 和置信区间 (CI).
主要成果:
- 较高的PRAL和NEAP分数与增加的谷物摄入量和减少的水果和蔬菜摄入量相关.
- 增加的NEAP分数也显示了乳制品,豆类,坚果和种子的摄入量减少.
- 经过对混因子进行调整后,高PRAL (第二/第三次) 增加了5.9x/10.97x的死亡风险;高NEAP (第二/第三次) 增加了4.46x/12.3x的死亡风险.
结论:
- 饮食中的酸含量与肝硬化相关的死亡率增加有显著的关联.
- 研究结果表明,需要对肝硬化患者的机制和最佳DAL水平进行进一步研究.
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