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延长分子动力学和二次结构内观,以确定尼帕病毒的双重目标抑制剂,施加批准的小分子重定位

Siyun Yang1, Supratik Kar2

  • 1Chemometrics and Molecular Modeling Laboratory, Department of Chemistry and Physics, Kean University, 1000 Morris Avenue, Union, NJ, 07083, USA.

Scientific reports
|February 15, 2024
PubMed
概括

尼帕病毒 (NiV) 构成了流行病威胁. 重用药物将Iotrolan和Iodixanol确定为NiV进入和组装的双重抑制剂,而Rutin和Lactitol则准矩阵蛋白.

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Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
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