Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Inhaled Medications01:23

Inhaled Medications

261
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
261
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

339
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
339
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

134
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
134
Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

2.8K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.8K
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

451
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
451
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

292
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
292

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Advancing Rare Cancer Therapeutics: Osimertinib-Loaded Inhaled PLGA Nanoparticles for Mesothelioma Treatment.

AAPS PharmSciTech·2026
Same author

Liposomal Amodiaquine for Localized Therapy of Non-Small Cell Lung Cancer (NSCLC).

AAPS PharmSciTech·2026
Same author

A Microemulsion for Oral Delivery of Nintedanib - QbD-Enabled Formulation Development, In-Vitro Characterization & In-Vivo Pharmacokinetic Assessment.

The AAPS journal·2025
Same author

Novel Polymorphic Patterns for Elacestrant Dihydrochloride.

Pharmaceutics·2025
Same author

Enhanced Intranasal Delivery of Atorvastatin via Superparamagnetic Iron-Oxide-Loaded Nanocarriers: Cytotoxicity and Inflammation Evaluation and In Vivo, In Silico, and Network Pharmacology Study for Targeting Glioblastoma Management.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Development and In-Vitro Evaluation of Doxorubicin-Loaded Methacrylate Gelatin (GelMa)-Acrylamide Hydrogels for the Treatment of Malignant Pleural Mesothelioma.

Pharmaceutical research·2024
Same journal

Vegetable Butter-Based Nanocarriers: Do Nanoparticulation and Quercetin Loading Modulate In vitro Cellular Effects Involved in Wound Healing?

AAPS PharmSciTech·2026
Same journal

Hot-Melt Extrusion of Bupropion with Three Ethylcellulose Grades for Pellet Feedstock Preparation and Screw-Based 3D Printing of Sustained-Release Tablets.

AAPS PharmSciTech·2026
Same journal

Enhanced Stability and Transdermal Delivery of Semaglutide Using an L-Arginine Based Dissolving Microneedle System.

AAPS PharmSciTech·2026
Same journal

The Preparation and Physicochemical Characterization of a Triple Synergistic Nanoplatform Designed for Targeted Subcutaneous Delivery of Sitagliptin with Potential for β-Cell Preservation.

AAPS PharmSciTech·2026
Same journal

Repurposing Non-oncologic Drugs via Targeted Nanocarriers for Cancer Therapy: Mechanisms, Synergistic Combinations, and Clinical Translation.

AAPS PharmSciTech·2026
Same journal

Targeting Permeability Barriers By Strategic Selection of Thiol Containing Coformer for Novel Cocrystals of Metformin.

AAPS PharmSciTech·2026
查看所有相关文章

相关实验视频

Updated: Jul 3, 2025

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

853

新型吸入剂型的辅助剂:概述

Carol Yousry1,2,3, Mimansa Goyal1, Vivek Gupta4

  • 1Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, 8000 Utopia Parkway, Queens, New York, 11439, USA.

AAPS PharmSciTech
|February 15, 2024
PubMed
概括
此摘要是机器生成的。

肺部药物输送为呼吸系统疾病和全身吸收提供有针对性的肺部治疗. 本综述探讨了新型吸入剂型和设备的基本辅助剂,克服了交付方面的挑战.

关键词:
辅助剂 辅助剂 辅助剂吸入吸入的方法肺的 肺的 肺的 肺的纳米颗粒是一种纳米粒子.新的剂量形式是新的.

更多相关视频

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.7K
Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

7.7K

相关实验视频

Last Updated: Jul 3, 2025

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

853
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.7K
Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

7.7K

科学领域:

  • 制药科学 制药科学
  • 呼吸系统医学 呼吸系统医学
  • 药物运输 药物运输 药物运输

背景情况:

  • 肺部药物输送的目标是肺部疾病,如囊性纤维化,喘和肺癌.
  • 它提供了非侵入性的全身吸收,较低的剂量和比其他途径更少的副作用.
  • 挑战包括机械/化学障碍和FDA批准的有限的辅助剂用于吸入产品.

研究的目的:

  • 审查用于新型吸入药物剂型的辅助剂.
  • 讨论助剂在各种吸入器件 (pMDIs,DPIs,雾化器) 中的作用.
  • 通过辅助剂选择突出克服肺部输送挑战的战略.

主要方法:

  • 科学文章和FDA批准的辅助剂的文献评论.
  • 在不同吸入剂型中对辅助剂功能的分析.
  • 对辅助剂与各种吸入器件的兼容性进行检查.

主要成果:

  • 确定了关键的辅助成分,使吸入配方的物理和化学稳定性.
  • 证明了辅助剂如何通过pMDIs,DPIs和雾化剂促进有效的药物输送.
  • 强调了辅助剂选择在新型吸入产品开发中的关键作用.

结论:

  • 助剂对于开发有效和稳定的肺药物递送系统至关重要.
  • 精心选择辅助剂对于克服吸入挑战和优化治疗结果至关重要.
  • 对新型辅助剂的进一步研究可以扩大吸入疗法的选择.