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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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相关实验视频

Updated: Jul 3, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Na&#239;ve CD4+ T Cells Using a TGF-&#946;-containing Protocol
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IL-23稳定了瘤微环境中的T细胞项目.

Tobias Wertheimer1, Pascale Zwicky1, Lukas Rindlisbacher1

  • 1Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

Nature immunology
|February 15, 2024
PubMed
概括

互白素-23 (IL-23) 通过激活调节性T细胞 (Tregs) 来促进瘤生长. 准IL-23/IL-23R通路可能会增强抗瘤免疫力.

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相关实验视频

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科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.

背景情况:

  • 介乐金-23 (IL-23) 是一种与瘤进展相关的促炎性细胞因子.
  • 通过IL-23促进瘤生长的确切机制仍然不完全理解.

研究的目的:

  • 阐明瘤微环境中IL-23的细胞来源和点.
  • 研究IL-23在调节T细胞 (Treg) 功能和瘤促进中的作用.

主要方法:

  • 从小鼠和人类瘤的瘤相关巨细胞 (TAMs) 中分析IL-23的产生.
  • 在瘤微环境中识别和描述IL-23感应调节性T细胞 (Tregs).
  • 在临床前癌症模型中,Tregs中的IL-23受体 (Il23r) 的基因切除.

主要成果:

  • 与瘤相关的巨细胞 (TAMs) 被确定为IL-23.3的主要来源.
  • 发现瘤透Tregs的一个子集能够感知IL-23并表现出抑制性表型.
  • 在Tregs中对Il23r的遗传删除取消了IL-23.3的促进瘤效应.
  • 通过Foxp3.3,IL-23信号传递被证明对通过Foxp3.3维持和稳定效应体Tregs至关重要.

结论:

  • IL-23主要通过增强瘤透Tregs的抑制功能来促进瘤生长.
  • 针对IL-23/IL-23R轴是一个潜在的治疗策略,可以刺激抗瘤免疫力.