相关实验视频
Updated: Jul 3, 2025

00:07
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
7.3K
通过结合常见的遗传突变和TERT促进剂甲基化在乳头甲状腺癌中的风险分层
Ye Sang1, Guanghui Hu1, Junyu Xue2
1Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan Second Road, Guangzhou, China.
Endocrine
|February 15, 2024
概括
分析BRAF/RAS突变,TERT促销物突变和TERT促销物甲基化一起,可以改善乳头甲状腺癌 (PTC) 的风险分层. 这种综合分析更有效地识别高风险的PTC患者.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 已经确立的甲状腺 papillary 癌症 (PTC) 风险分层利用 TERT 促进体和 BRAF/RAS. 的体质突变.
- 新出现的证据将TERT促进剂甲基化与甲状腺癌的不良特征联系起来.
研究的目的:
- 在PTC中全面探索BRAF/RAS突变,TERT促进体突变和TERT促进体甲基化的预后价值.
- 确定这些基因变异对PTC患者结果的综合影响.
主要方法:
- 在382名PTC患者中分析了BRAF/RAS突变,TERT促进体突变和TERT促进体甲基化.
- 这些变化与临床特征和患者结果的相关性.
主要成果:
- 在13.6%的样本中发生了TERT促进物突变和高甲基化,与BRAF/RAS突变和不良结果相关.
- BRAF/RAS和TERT变化的同时存在 (11.8%的患者) 与晚期疾病特征有很强的相关性.
- 患有BRAF/RAS和TERT综合变化的患者的复发和进展率显著提高,无进展间隔风险增加10.35倍.
结论:
- 对BRAF/RAS突变,TERT促进子突变和甲基化的全面分析是识别高风险PTC患者的有效策略.
- 综合基因变异作为一个强大的生物标志物,用于预测侵袭性疾病和PTC的不良预后.
相关概念视频
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K

