相关实验视频

Updated: Jul 3, 2025

Peptide-based Identification of Functional Motifs and their Binding Partners

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

艾滋病毒,艾滋病毒特异性因素和女性心肌病

Yoko Kato¹, Bharath Ambale-Venkatesh², Mahim Naveed^3,4

¹Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

|February 15, 2024

概括

接受抗逆转录病毒治疗的艾滋病毒感染妇女表现出心脏炎症和纤维化增加,特别是在未抑制的病毒载量或低CD4计数的情况下. 这凸显了需要更好的坚持策略来预防心脏损伤的需要.

科学领域:

心脏病学心脏病学
传染性疾病传染性疾病
医疗成像医学成像

背景情况:

人类免疫缺陷病毒 (HIV) 感染者患心血管疾病 (CVD) 的风险更高.
心脏磁共振 (CMR) 在艾滋病毒 (PWH) 感染者中显示心肌纤维化,炎症和肥胖症的增加.
以前的研究经常使用健康的志愿者,并专注于男性,限制了女性的理解.

研究的目的:

研究艾滋病毒和特定因素与女性中CMR衍生的心脏表型之间的关联.
评估艾滋病毒感染妇女的心肌纤维炎症,纤维化和肥胖症 (WWH).

主要方法:

利用了来自妇女机构间艾滋病毒研究的数据.
通过CMR评估心肌原生T1 (纤维炎症),细胞外体积分数 (纤维化) 和甘油三含量 (稳定性).
使用多变量线性回归和元分析来评估关联.

主要成果:

与没有艾滋病毒的妇女相比,艾滋病毒感染的妇女表现出更高的肌肉心本土T1 (纤维炎症).
较高的原生T1在病毒病或低CD4+计数中更为明显.
较低的CD4+计数也与细胞外体积分数 (纤维化) 的增加有关;在低CD4+计数的WWH中,观察到较少的肥胖症.

结论:

与HIV阴性女性相比,接受抗逆转录病毒治疗 (ART) 的艾滋病毒感染女性表现出心肌纤维炎症的增加.
这种纤维性炎症会因未抑制的病毒病或CD4+淋巴缺血症而恶化.
这些发现强调了需要改善ART坚持和理解潜在感染,以减少心脏末端器官损伤的必要性.

关键词:

艾滋病病毒艾滋病病毒艾滋病病毒妇女机构间艾滋病毒研究 (WIHS)抗逆转录病毒药物治疗心脏磁共振是一种心脏磁共振.心肌纤维炎症 - - 心肌纤维炎症

更多相关视频

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Published on: January 5, 2016

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples

Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples

Published on: July 6, 2014

相关概念视频

Sexually Transmitted Infections

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Pathophysiology of Heart Failure

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Imbalances in Cardiac Output

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...