通过超高性能液体染色学四极管轨道质谱法快速分类和识别三种不同的Zanthoxylum物种中的化学成分
Lexin Shu1, Shumin Zhang1, Huixin Qiu1
1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.
Journal of separation science
|February 15, 2024
概括
这项研究开发了一种快速方法,使用超高性能液体染色学-四极体-轨道仪-质谱法来识别桑托西的成分. 它区分了山东Zanthoxylum bungeanum和武都Zanthoxylum bungeanum等品种,有助于质量控制.
科学领域:
- 药理学是指药理学,即药理学是指药理学.
- 分析化学 分析化学
- 草药分析 草药分析
背景情况:
- 桑托西种类是广泛使用的药用和食用草药,具有复杂的化学特征.
- 桑托西组成的品种差异需要精确的识别方法.
- 现有的方法可能不足以快速分类和组件分析.
研究的目的:
- 建立Zanthoxylum主要成分的快速分类和识别方法.
- 分析和区分关键Zanthoxylum品种的化学成分.
- 为Zanthoxylum的药理学研究和质量控制提供参考.
主要方法:
- 使用超高性能液态色谱四极-轨道-质谱仪 (UHPLC-Q-轨道-MS) 进行高分辨率分析.
- 研究了关键化学成分的特征碎片和中性损失.
- 分析的样本来自山东桑托克斯邦,武都桑托克斯邦和桑托克斯树叶.
主要成果:
- 在研究Zanthoxylum品种中成功识别了48种常见的和24种独特的化学成分.
- 总结了主要化合物类的碎片化模式,包括黄类,类和有机酸.
- 证明了该方法在区分不同Zanthoxylum物种和品种的有效性.
结论:
- 开发的UHPLC-Q-Orbitrap-MS方法可以根据Zanthoxylum品种的化学形状进行快速准确的分类.
- 这种方法对于理解药理动力学基础和确保各种桑托西资源的质量控制是有价值的.
- 这些发现支持Zanthoxylum在传统和现代应用中的持续使用和发展.
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