间歇性缺氧的单次序列不会改变有能力的个体的伸展反射刺激性
Andrew Q Tan1, Christopher Tuthill2,3, Anthony N Corsten3
1Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA.
Experimental physiology
|February 15, 2024
概括
一次暴露于急性间歇性缺氧 (AIH) 并没有改变健壮个体的肌肉伸展反射刺激性. 拉伸反射反应在活跃收缩期间增加,与被动收缩相比,无论AIH暴露.
科学领域:
- 神经科学是一个神经科学.
- 身体生理学 身体生理学
- 康复科学 康复科学 康复科学
背景情况:
- 性,通常在脊髓损伤中出现,涉及过度的伸展反射.
- 急性间歇性缺氧 (AIH) 在动物模型中显示出诱导脊柱可塑性和调节伸展反射的潜力.
- 了解AIH对人类伸展反射的影响对于潜在的治疗应用至关重要.
研究的目的:
- 量化单次AIH暴露对健壮个体肌肉伸展反射刺激能力的影响.
- 为了调查AIH是否会在被动和主动脚扰动期间改变伸展反射反应.
- 为了确定AIH是否会影响被动和活跃条件之间的伸展反射兴奋度的差异.
主要方法:
- 有能力的参与者接受了一次AIH或假暴露.
- 测量了底肌的伸展反射刺激性,使用脚上的斜坡和保持角度扰动来测量.
- 参与者进行了被动脚运动和自愿匹配的活跃收缩.
主要成果:
- 单次AIH暴露在被动或活跃条件下并没有显著改变 Soleus 肌肉伸展反射刺激能力.
- 与被动运动相比,在活跃收缩期间,拉伸反射反应明显高于被动运动,无论AIH还是假冒暴露.
- 在AIH暴露和收缩类型 (被动与活性) 之间没有发现显著的相互作用.
结论:
- 一次接触AIH似乎没有足够地参与脊柱抑制途径,以修改健壮个体的伸展反射反应.
- 在活跃收缩期间观察到的伸展反射的增加突显了自愿驱动的影响.
- 需要进一步研究涉及重复的AIH暴露和像行走这样的功能性任务,以探索对的潜在治疗益处.
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