在胆管癌中,收入与存活率之间的关联:基于亚型的综合分析
Calvin X Geng1, Anuragh R Gudur1, Jagannath Kadiyala1
1Department of Medicine, University of Virginia, Charlottesville, VA, USA.
Annals of hepato-biliary-pancreatic surgery
|February 15, 2024
概括
较低的收入与更糟糕的生存率和较少的胆管癌 (CCA) 手术有关. 社会经济地位显著影响治疗和结果,因瘤位置而异.
科学领域:
- 在瘤学瘤学.
- 医疗保健服务研究 医疗服务研究
- 流行病学 流行病学
背景情况:
- 胆管癌 (CCA) 的社会经济健康决定因素尚未完全理解.
- 研究社会经济地位对CCA治疗和生存的影响至关重要.
研究的目的:
- 评估社会经济地位如何影响CCA患者的初始治疗决策.
- 评估社会经济地位对CCA生存结果的影响.
- 根据主要瘤的解剖位置进行子分析.
主要方法:
- 一项使用2018年SEER-18数据库 (2004-2015) 的观察性研究.
- 5,476名CCA患者按家庭收入中位数 (低于高) 分类.
- 对73%的患者进行了生存分析,并使用R-studio进行了完整的随访数据.
主要成果:
- 收入较高的患者更有可能接受手术,化疗和局部瘤破坏.
- 低收入患者在2年和5年内总体和癌症特异性死亡率较高.
- 治疗和生存差异因瘤的位置 (肝脏内,周围,远部) 有显著差异.
结论:
- 较低的收入与增加的癌症特异性死亡率和减少CCA的手术切除率有关.
- 在不同CCA瘤位置之间存在治疗选择和结果的显著差异.
- 需要基于人口的策略来解决社会经济差异,并改善CCA患者的治疗结果.
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