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应用的平板电脑在平板电脑技术,以设计和表征立即释放和改性释放的药片的提摩洛尔马莱酸盐
Sachin S Gaikwad1, Sanjay J Kshirsagar1
1Department of Pharmaceutics, MET's Institute of Pharmacy, Affiliated to Savitribai Phule Pune University, Bhujbal Knowledge City, Adgaon, Nashik 422003, India.
Heliyon
|February 15, 2024
概括
这项研究开发了一种新的药片中的药片配方,用于提摩洛酸 (TM),以改善高血压治疗. 优化的配方在体外实现了显著的药物释放和胀,提供了一个有前途的单单元剂量形式.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 心血管药理学心血管药理学
背景情况:
- 高血压是全球主要的死亡原因.
- 蒂莫洛 (Timolol maleate,TM) 是一种非选择性β-阻断剂,是一种常见的高血压治疗方法.
- 目前的配方可能缺乏最佳的释放特征,以有效管理.
研究的目的:
- 设计和开发一种创新的药片中的药片 (TIT) 制剂,用于提摩洛尔酸 (TM).
- 为了实现核心的修改释放和外的快速释放,以单剂型.
- 为了优化配方,使用3 ^ 2完整的因数设计来增强药物输送.
主要方法:
- 用于内部修改释放核心的湿颗粒利用含有藻酸盐 (SA) 和基甲基纤维素 (HPMC K4M).
- 采用了 3^2 完整的因子设计来研究 SA 和 HPMC K4M 对体外释放和胀的影响.
- 开发了一种使用croscarmellose和微晶纤维素 (MCC) 的即时释放外,压涂在优化的核心上.
主要成果:
- 优化的内核配方 (F6) 在24小时内体外释放药物的96.38%,胀指数为52.7%.
- 核心和外片的物理化学特性都在可以接受的范围内.
- 福里埃变换红外 (FTIR) 和差分扫描热量计 (DSC) 证实没有药物辅助剂相互作用.
结论:
- 开发的片内片 (TIT) 配方提供了一个可行的单单元剂型,用于修改和快速释放蒂莫洛尔酸盐.
- 与TIT-3相比,TIT-2配方被选为最终产品,因为它的组成更简单,分解更快.
- 这种新的方法有可能通过优化药物输送来改善高血压管理.
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