使用修改格拉斯哥预后得分预测肺癌的结果:系统性审查和元分析
Yonghua Min1, Xiaofeng Li2, Huafei Chen3
1Yonghua Min, Department of Chest Disease Center, Zhejiang Rongjun Hospital, 309 Shuangyuan Road, Jiaxing, Zhejiang Province 314000, P.R. China.
Pakistan journal of medical sciences
|February 15, 2024
概括
修改后的格拉斯哥预后评分 (mGPS) 与肺癌患者的生存结果较差有关. 这一分数可以作为一个有价值的生物标志物来预测肺癌的预后.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 临床预后 临床预后
背景情况:
- 修改后的格拉斯哥预后评分 (mGPS) 已被提议作为肺癌 (LC) 的潜在生物标志物.
- 在LC患者的整体存活率 (OS) 和无进展存活率 (PFS) 方面,mGPS的预后值需要进一步澄清.
研究的目的:
- 调查修改后的格拉斯哥预后得分 (mGPS) 与肺癌患者的整体生存期 (OS) 或无进展生存期 (PFS) 之间的相关性.
主要方法:
- 在多个数据库 (PubMed,Cochrane Library,EMbase,CINAHL,Trip Database,Worldwide Science,Google Scholar) 进行了系统的文献搜索,寻找2021年5月30日之前发表的相关研究.
- 聚合危险比率 (HRs) 和95%置信区间 (CI) 被计算出来,以评估mGPS与生存结果之间的关联.
主要成果:
- 对28项涉及9748名LC患者的研究分析表明,mGPS升高 (≥0) 与较差的生存状况 (HR=1.54;95% CI,1.32-1.77) 和PFS (HR=1.49;95% CI,1.17-1.82) 有显著关联.
- 在mGPS得分为1或2和OS之间发现了显著的相关性,但不是PFS.
- 根据种族分类的子组分析表明,亚洲和高加索肺癌患者队列中mGPS ≥0与更糟糕的生存状况有关.
结论:
- 阳性mGPS显然与肺癌的不良生存结果有关.
- 修改后的格拉斯哥预后评分 (mGPS) 显示了作为肺癌患者预后生物标志物的潜力.
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