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在患有非阻塞性冠状动脉疾病的女性和男性中,复合性斑块进展

Caroline Annette Berge Hondros^1,2, Ingela Khan², Margrete Solvik¹

¹Department of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway.

International journal of cardiology. Heart & vasculature

|February 15, 2024

概括

在非阻塞性冠状动脉疾病 (CAD) 中,女性表现出较高的斑块负担和稳定的组成,而男性则经历不稳定的斑块的更快进展. 这突显了CAD进展中的基于性别的差异.

科学领域:

心血管成像 - 心血管成像
干预心脏病学干预心脏病学
血管生物学血管生物学

背景情况:

冠状动脉疾病 (CAD) 的风险与斑块的进展和组成有关.
在非阻塞性CAD中,性别之间的构成性斑块进展的差异未得到充分研究.

研究的目的:

研究非阻塞性CAD患者的斑块组成和进展的基于性别的差异.
为了比较女性和男性之间的斑块负担和组成随着时间的推移而变化.

主要方法:

从31名患有非阻塞性心脏病的患者进行的连续冠状动脉计算机断层扫描血管学 (CCTA).
对所有冠状动脉段的定量和定性斑块分析.
男性和女性之间的斑块进展和组成的比较.

主要成果:

女性年龄较大,基线总斑块负担较高,化程度较高,纤维脂肪/死核斑块较少.
与女性相比,男性的纤维脂肪斑的进展更快,纤维斑的减少更快.
在随访时,女性保持了较高的总斑块负担和稳定的组成,而男性增加了纤维脂肪和死核斑块.

结论:

患有非阻塞性CAD的女性表现出较高的斑块负担和随着时间的推移稳定的斑块组成.
男人表现出不稳定,低衰减纤维脂肪斑块的更快进展.
系列CCTA揭示了非阻塞性CAD中斑块进展的明显的性别特异性模式.

关键词:

冠状动脉计算机断层扫描血管图谱.非阻塞性冠状动脉疾病斑块的组成斑块的组成斑块发生的进展.性差异性差异性差异性差异性差异性差异性差异性

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