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从INFORM注册平台对瑞典的复发癌症儿童实施针对性治疗的数据

Sofia Wallin¹, Ingrid Øra², Gabriela Prochazka³

¹Division of Pediatric Oncology, Department of Women and Children´s Health, Karolinska Institutet, Stockholm, Sweden.

Frontiers in oncology

|February 15, 2024

概括

在INFORM注册表中,儿童癌症患者的瘤被测序以找到治疗点. 虽然可操作的目标是常见的,但在本研究中,匹配的向治疗没有显著改善生存结果.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
儿科儿科儿科

背景情况:

儿童癌症仍然是瑞典的主要死亡原因,特别是在复发或高风险病例中.
国际INFORM注册表收集了儿童癌症患者的瘤样本,用于分子表征.
下一代测序 (NGS) 用于识别这些瘤中的潜在治疗点.

研究的目的:

分析INFORM注册表中瑞典儿童的数据.
为了研究患者的特征,生存率和测序结果.
确定分子发现是否指导针对性治疗的管理及其影响.

主要方法:

进行了基于注册表的描述性分析.
分析了INFORM注册表 (2016-2021) 中的184名瑞典儿科癌症患者的数据.
瘤样本使用NGS进行了全面的分子分析.

主要成果:

软组织/骨肉瘤和高度质瘤是最常见的诊断.
在88%的分析样本中发现了可操作的分子标.
24名患者接受了匹配的向治疗,但与其他治疗相比,整体或无进展生存率没有显著改善.

结论:

该INFORM研究证明了对儿科高风险瘤进行测序的可行性.
来自测序的分子数据可以为临床医生提供潜在的可操作目标.
虽然在这个群体中并不普遍有益,但INFORM分析具有作为指导针对特定个体的向治疗的护理标准的潜力.

关键词:

分子诊断技术分子诊断技术分子向疗法是指分子向疗法.儿科癌症儿科癌症儿科瘤学儿科瘤学精准医学是一门精准医学.

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